Paternal contribution to early embryonic development in severe male factor patients
نویسندگان
چکیده
منابع مشابه
Mouse Zygotes Respond to Severe Sperm DNA Damage by Delaying Paternal DNA Replication and Embryonic Development
Mouse zygotes do not activate apoptosis in response to DNA damage. We previously reported a unique form of inducible sperm DNA damage termed sperm chromatin fragmentation (SCF). SCF mirrors some aspects of somatic cell apoptosis in that the DNA degradation is mediated by reversible double strand breaks caused by topoisomerase 2B (TOP2B) followed by irreversible DNA degradation by a nuclease(s)....
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STUDY OBJECTIVE Understanding causes of variation in birth weight has been limited by lack of sufficient sets of data that include paternal birth weight. The objective was to estimate risks of low birth weight dependent on parental birth weights and to estimate father-mother-offspring correlations for birth weight to explain the variability in birth weight in terms of effects of genes and envir...
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FTER parental exposure to mutagens and subsequent mating, adverse A genetic effects may manifest sequentially by preimplantation losses of fertilized ova and zygotes, early fetal deaths, and sterility and semisterility in F, progeny ( CATTANACH 1964; EPSTEIN et al. 1970a). Effects of ionizing irradiation of the male or of sperm in uitro on fertilization and subsequent development of the zygote ...
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ژورنال
عنوان ژورنال: Fertility and Sterility
سال: 2019
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2019.07.832